When Hellboy, Liz Sherman, and Abe Sapien are assigned to investigate the haunted mansion of a publicity-hungry billionaire, they uncover a plot to resurrect a beautiful but monstrous vampire from Professor Bruttenholm's past. Hellboy will have to fight harpies, hellhounds, a monstrous werewolf, and possibly the terrible goddess Hecate herself before they can put an end to her massacre.